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Sildenafil citrate, sold under the names Viagra, Revatio and generically under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. ...




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Don't Take Viagra Pill With This…

Don't Take Viagra Pill With This…
Don't Take Your Pill With This...

You're trying to eat properly and live a healthier lifestyle. So what could be better than a nice glass of fruit juice to wash down your little blue pill, right?

But if the juice happens to be grapefruit, taking it with could lead to some very unhealthy consequences.

Certain compounds in grapefruit juice (Seville oranges and tangelos have also been implicated) can increase the amount of the drug in your system. The juice could potentially raise levels enough to cause harm. Here's how researchers believe this happens:

? Enzymes in the small intestine normally prevent many drugs, like Viagra, from fully entering the blood stream.
? When you drink grapefruit juice, certain compounds in the juice block those intestinal enzymes.
? This prevents the active ingredient in your pill from metabolizing or breaking down properly, which can lead to too much getting into your system.
? An overdose of can cause toxic side effects like chest pain, nausea, irregular heartbeat or feeling faint or light headed. You should see a doctor if any of these side effects occur.
Viagra Pill + Grapefruit Juice = Increased Risk For 24 Hours

The effect of grapefruit juice can last up to 24 hours after you drink it. Therefore, even if you take a pill long before or after drinking the juice, there could still be a bad interaction from dangerously high levels of the drug coursing through your bloodstream.

If you get too much in your system, it can damage your organs or impair their normal functioning. (Learn more about the side effects, precautions, and other important information about the drug here.)

To prevent

such an interaction from happening, doctors recommend not taking a pill within 24 hours or more of drinking grapefruit juice. If you take every day, do not drink grapefruit juice at all until the medication is discontinued. Instead, use orange juice.

And is not the only erectile dysfunction drug to exhibit this interaction. Both Cialis and Levitra are also affected by grapefruit juice.

How It Was Discovered

Hard to believe that this interaction between certain drugs and grapefruit juice was discovered accidentally. About ten years ago, researchers were testing a drug and used grapefruit juice to mask the bad taste.

They noticed the drug showed up in their patients' blood samples several times stronger than in past studies. And this, naturally, caused a large increase in side effects. That's when scientists began watching for the effects of grapefruit juice on certain medications.

Since then, Viagra, Cialis, Levitra and other drugs have exhibited the same negative interaction. Some antihistamines, cholesterol drugs, blood pressure drugs, psychiatric medications like antidepressants, pain drugs, immunosuppressants, and others should also not be taken with grapefruit juice.

You can find a list of the more common drugs affected by grapefruit on Wikipedia.

To learn more about the ED drug Viagra, visit our Articles library.

And always consult with your doctor or pharmacist if you have questions about taking with any food, drug or supplement.

Resource:
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